Affymetrix expression data used to estimate p-values in small microarray experiments
Microarray data typically have small numbers of observations per gene, which can result in low power for statistical tests. We investigate permutation based methods for estimating p-values. Data from Affymetrix MOE430v2 microarrays were used to study p-value behavior. Three RMA normalized gene expression datasets were used. Each dataset compared 2 conditions and each condition had 3 biological replicates. Biological detail such as the conditions and the type of biological replicate were not specified.
Estimating p-values in small microarray experiments