Diversity Outcross (DO) QTL Mapping data - high fat diet, multiple phenotypes
DescriptionA panel of 150 Diversity Outbred (DO) mice were phenotyped over a period of 24 weeks. 100 of the mice received a chow diet and 50 received a high fat diet from weaning until sacrifice. The mice were genotyped at 7,854 SNPs on the Mouse Universal Genotyping Array (MUGA) and quantitative trait locus (QTL) mapping was performed on the phenotypes. Animals were subject to a battery of noninvasive physiological measurements to obtain clinical parameters, including: serum cholesterol (at 8 and 24 weeks), early and late measurements of clinical plasma chemistries (lipids, glucose, insulin) and body composition (weight, percent fat, lean tissue mass). Coat color was also recorded. The genotypes were reconstructed using a hidden Markov model that produced genotype probabilities for each sample at each SNP. These were then condensed down to eight founder allele dosages that were used to map each trait. Mapping was carried out with QTLRel, which accounts for the complex genetic relationships between mice. ReferenceUse of these data should cite the following references: High-Resolution Genetic Mapping Using the Mouse Diversity Outbred Population The Diversity Outbred Mouse Population DatasetsPhenotype Data
Array Genotype Data
Reconstructed Genotype Data for Svenson et al. Genetics 2012
Reconstructed Genotype Data for Churchill et al. Mammalian Genome 2012
QTL Results for Svenson et al. Genetics 2012
QTL Results for Churchill et al. Mammalian Genome 2012
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