2012

Inferring Genetic Interaction Networks to Predict Phenotype

Genetic analysis of behavior in advanced mouse populations

Stressing the ends: Alternative polyadenylation in tumors and other stressed cells

2011

Managing the message: Alternative polyadenylation under cellular stress conditions
Joel Graber
Bowdoin College, Brunswick, ME, October 28, 2011. Talk

Pleiotropy and Genetic Interactions
Greg Carter
CIFAR Genetic Networks, New York, NY, October 19, 2011. Talk

Messages are the medium: RNA processing in sickness and health
Joel Graber
JAX-MDIBL Joint Scientific Symposium, Bar Harbor, ME, September 15, 2011. Talk

The Regulatory System Controlling Mammalian Recombination Hotspots
Petko Petkov
Gordon Research Conference on Mammalian Gametogenesis & Embryogenesis, Waterville Valley Resort, Waterville Valley, NH, August 21-26, 2011. Talk

Variation in Body Composition in Genetically Diverse Mice

Greg Carter
Mouse Genetics 2011, Washington, DC, June 25, 2011. Poster

Center for Genome Dynamics (PDF 19 MB)

Gary Churchill
National Centers for Systems Biology Annual Meeting, Duke University, Durham, NC, June 16-17, 2011. Talk

Systems Genetics of Body Composition

Greg Carter
National Centers for Systems Biology Annual Meeting, Duke University, Durham, NC, June 16-17, 2011. Talk

Independent Studies in Computational Biology (PDF 1.6 MB)

Susan McClatchy
National Centers for Systems Biology Annual Meeting, Duke University, Durham, NC, June 16-17, 2011. Talk

Predictive Modeling of Genetic Interactions

Greg Carter
38th Maine Biological and Medical Sciences Symposium, MDIBL, Bar Harbor, ME, April 15, 2011. Talk

2010

Bayesian Inference of the Phenotype-Genotype Network Topology (PDF 0.7 MB)

R.S. Hageman, M.S. Leduc, B. Paigen, R. Korstanje and G.A. Churchill
14th International Conference on Research in Computational Molecular Biology, Lisbon, Portugal, August 12-15, 2010. Poster

Center for Genome Dynamics (PDF 11.1 MB)

Gary Churchill
National Centers for Systems Biology Annual Meeting, Institute for Systems Biology, Seattle, WA, July 12-13, 2010. Talk

Chromosome location modulates recombination hotspot activity (PDF 1.3 MB)

Petko M. Petkov, Lorin Petros, Evelyn Sargent, Tim Billings, Terry Hassold, Karl Broman, and Ken Paigen
2010 Gordon Research Conference on Meiosis, Colby Sawyer College, New London, NH, June 13-18 2010. Poster

Stochastic Variation of Transcript Abundance in C57BL/6J Mice (PDF 2.5 MB)

Peter T. Vedell, Karen L. Svenson and Gary A. Churchill
Systems Biology of Stem Cells, University of California-Irvine, Irvine, CA, May 24-25, 2010. Poster

Behavioral Genetics Analysis in the Collaborative Cross - Symposium Organized by E. Chesler and L. Tarantino
International Behavioral and Neural Genetics Society Meeting, Dalhousie University, Halifax, Canada, May 2010

Intro: Behavioral genetics in the collaborative cross and related populations - E. Chesler
Genetic dissection of anxiety like behaviors using emergent CC mice - A. Palmer
Selective breeding for increased home cage physical activity in CC and Hsd:ICR mice - J. Rhodes
Gene networks in a heterogenous stock population of the Collaborative Cross - R. Hitzemann
An interdisciplinary program for systems genomics of complex behaviors - L. Tarantino

The Trouble with Triplets: Can we Infer Causality from Omics Data? (PDF 1.8 MB)

Gary A. Churchill
CTC2010 - Complex Trait Consortium Annual Meeting, Chicago, IL, May 5-8, 2010. Talk

A Survey of Gene Expressin in 17 Mouse Tissues with Biological Replication (PDF 3.6 MB)

Ricardo A. Verdugo, Peter T. Vedell, Joel H. Graber, Beverly Paigen and Gary A. Churchill
CTC2010 - Complex Trait Consortium Annual Meeting, Chicago, IL, May 5-8, 2010. Poster

Customized Genotyping Array Development - Clinical Trial with Genetic Information

Hyuna Yang
Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, April 2010. Talk

2009

Educational outreach and distance learning techniques- Dragons and Drakes

Randy Von Smith
New Mexico Nano(bio)science Education Network (NM-NEN) 2nd Workshop, Santa Fe, NM, September 27-28, 2009. Talk

Training and Outreach, Center for Genome Dynamics (PDF 2.2 MB)

Randy Von Smith
National Centers for Systems Biology Annual Meeting, NIH, Bethesda, MD, July 12-14, 2009. Talk

Center for Genome Dynamics (PDF 17.3 MB)

Gary Churchill
National Centers for Systems Biology Annual Meeting, NIH, Bethesda, MD, July 12-14, 2009. Talk

National Centers for Systems Biology Portal (PDF 1.3 MB)

Imogen Hurley
National Centers for Systems Biology Annual Meeting, NIH, Bethesda, MD, July 12-14, 2009. Talk

Revisiting Gene Deserts: New Definitions and Investigations of Overlapping Features (PDF 1MB)

Nicole P Leahy, Alex Allison, Cheryl Zapata, Joel H Graber
Advisory Board Meeting, Center for Genome Dynamics, The Jackson Laboratory, Bar Harbor, ME, July 6, 2009. Poster

Importance of Randomization in Microarray Experimental Designs with Illumina Platforms (PDF 4.1 MB)

Ricardo A Verdugo, Christian F Deschepper and Gary A Churchill
Advisory Board Meeting, Center for Genome Dynamics, The Jackson Laboratory, Bar Harbor, ME, July 6, 2009. Poster>

Multiple mutations perturb a small number of pathways in an HDL mutagenesis screen (PDF 4.6 MB)

Rachael S. Hageman, Aleksandra Aljakna, Karen L. Svenson, Gary A. Churchill and Ron Korstanje
Advisory Board Meeting, Center for Genome Dynamics, The Jackson Laboratory, Bar Harbor, ME, July 6, 2009. Poster

Trans-regulation of meiotic recombination hotspots by Rcr1 (PDF 0.5 MB)

Emil Parvanov, Siemon Ng, Petko Petkov and Kenneth Paigen
Advisory Board Meeting, Center for Genome Dynamics, The Jackson Laboratory, Bar Harbor, ME, July 6, 2009. Poster

GeniQuest: bringing computational biology to the high school classroom (PDF 1.6 MB)

Randy Von Smith, Chad Dorsey, Stephen Bannasch, Aubrey Smith, Francis Eberle, Jon Geiger and Gary A Churchill
Advisory Board Meeting, Center for Genome Dynamics, The Jackson Laboratory, Bar Harbor, ME, July 6, 2009. Poster

Independent Studies in Computational Biology: using distance learning to bring computational biology to the high school classroom (PDF 1.5 MB)

Randy Von Smith, Deborah McGann, Bob Gotwals, Keith Shockley, Shirngwern Tsaih, James Nadeau and Gary A Churchill
Advisory Board Meeting, Center for Genome Dynamics, The Jackson Laboratory, Bar Harbor, ME, July 6, 2009. Poster

CGDSNP : A High Qaulity Integrated Mouse SNPs Database (PDF 0.8 MB)

Lucie N. Hutchins, Yueming Ding, Jin P. Szatkiewicz, Randy Smith, Fernando Pardo-Manuel de Villena, Gary A Churchill and Joel H Graber
Advisory Board Meeting, Center for Genome Dynamics, The Jackson Laboratory, Bar Harbor, ME, July 6, 2009. Poster

Transcript Abundance Variation in C57BL/6J Male Mice under Normal Laboratory Conditions (PDF 7 MB)

Peter T Vedell, Karen L Svenson, Gary A Churchill
Advisory Board Meeting, Center for Genome Dynamics, The Jackson Laboratory, Bar Harbor, ME, July 6, 2009. Poster

Multiple mutations perturb a small number of pathways in an HDL mutagenesis screen (PDF 7.2 MB)

Rachael S. Hageman, Aleksandra Aljakna, Karen L. Svenson, Gary A. Churchill, and Ron Korstanje
International Symposium on Atherosclerosis --- Post-Satellite Symposium: High Density Lipoproteins and Atherosclerosis, New York, June 19-20, 2009. Poster

Linking Phenotype and Genotype: GeniQuest, an exploration of genetics (PDF 16.9 MB)

Randy Smith
CAMPY/PIMMS Career Day, Wesleyan University, Middletown, CT, May 19, 2009. Talk

Use Hidden Markov Model to Infer Haplotype Structure and Impute Missing Genotypes from Mouse SNPs (PDF 1.7 MB)

Jin P. Szatkiewicz, Glen L. Beane, Yueming Ding, Lucie Hutchins, Fernando Pardo-Manuel de Villena, Gary Churchill
NIH Site Visit, Center for Genome Dynamics, The Jackson Laboratory, Bar Harbor, ME, March 26, 2009. Poster

Importance of Randomization in Microarray Experimental Designs with Illumina Platforms

Ricardo A Verdugo, Christian F Deschepper, and Gary A Churchill
Gordon Research Conference. Quantitative Genetics & Genomics. Galveston, TX. February 2009. Poster

The Mouse Genome: It Takes Three to Make a Mouse

Fernando Pardo-Manuel de Villena
Gordon Research Conference. Quantitative Genetics & Genomics. Galveston, TX. February 2009. Talk

2008

Recombination landscape and genetic background – evolutionary conservation of regional but not local rates

Petkov, PM, Lorin Petros, Emil Parvanov, Siemon Ng, Rose Madeira, Evelyn Sargent, Timothy Billings, Kenneth Paigen
22th International Mammalian Genome Conference, Prague Czech Republic, November 2008. Talk

The trans-acting gene Rcr1 regulates the placement and activity of recombination hotspots

Emil Parvanov, Siemon Ng, Petko Petkov, Kenneth Paigen
22th International Mammalian Genome Conference, Prague Czech Republic, November 2008. Poster

High phenotypic diversity for metabolism and voluntary exercise in emerging lines of the Collaborative Cross

Wendy Foulds Mathes, Elissa Chesler, Fernando Pardo-Manuel de Villena, David Threadgill, Daniel Pomp
22th International Mammalian Genome Conference, Prague Czech Republic, November 2008. Talk

Detecting loci that confer susceptibility to dust-mite induced asthma using a panel of preCC mice

Samir Kelada, Kari Kubalanza, Greg Whitehead, Elissa Chesler, Darla Miller, Ken Manly, Gary Churchill, Fernando Pardo-Manuel de Villena,
David Schwartz, Francis Collins
22th International Mammalian Genome Conference, Prague Czech Republic, November 2008. Talk>

Genetic structure of the Pre-Collaborative Cross (PreCC) population

David Aylor, David Threadgill, Leonard McMillan, Gary Churchill, Elissa Chesler, Fernando Pardo-Manuel de Villena
22th International Mammalian Genome Conference, Prague Czech Republic, November 2008. Talk

The PreCC, a collaborative and interdisciplinary experiment based on emerging RI lines

Fernando Pardo-Manuel de Villena
6th Annual Retreat Department of Genetics, Atlantic Beach NC, September 2008. Talk

Male Infertility in Collaborative Cross Mice

Timothy A. Bell, Samie Ahmed, Summer Goodson, Deborah O’Brien, Fernando Pardo-Manuel de Villena
6th Annual Retreat Department of Genetics, Atlantic Beach NC, September 2008. Poster

CGDSNP : A High Qaulity Integrated Mouse SNPs Database (PDF 0.6 MB)

Lucie N Hutchins, Gary A Churchill, Joel H Graber
16th Annual International Conference Intelligent Systems for Molecular Biology, Toronto, Canada, July 2008. Poster

Recombination Anatomy of Mouse Chromosomes

Petkov PM
NIGMS Systems Biology Center Meeting. Princeton University. July 2008. Talk

GeniQuest: bringing computational biology to the high school classroom (PDF 1.9 MB)

Randy Von Smith, Chad Dorsey, Stephen Bannasch, Aubrey Smith, Francis Eberle, Jon Geiger, Gary A Churchill
NIGMS Systems Biology Center Meeting. Princeton Univesity. July 2008. Poster

Independent Studies in Computational Biology: using distance learning to bring computational biology to the high school classroom (PDF 1.6 MB)

Randy Von Smith, Deborah McGann, Bob Gotwals, Keith Shockley, Shirngwern Tsaih, James Nadeau, Gary Churchill
NIGMS Systems Biology Center Meeting. Princeton Univesity. July 2008. Poster

A High School Search for Genes: Identifying Genes Significant to the Atherosclerosis Phenotype (PDF 3.4 MB)

Renee Symonds, Ryan Keating, Chunan Liang, Deborah McGann, Melissa Martin, Randy Von Smith, Gary Churchill
NIGMS Systems Biology Center Meeting. Princeton Univesity. July 2008. Poster

Bringing Computational Biology to the High School Classroom to Narrow QTL (PDF 0.2 MB)

Deborah McGann, Randy Smith, Hyuna Yang, Sharon Tsaih, Keith Shockley, Gary Churchill
NIGMS Systems Biology Center Meeting. Princeton Univesity. July 2008. Poster

A New Mouse SNP Chip

Hyuna Yang, Yueming Ding, Gary A Churchill & Fernando Pardo-Manuel de Villena.
NIGMS Systems Biology Center Meeting. Princeton Univesity. July 2008. Poster

A New Mouse SNP Chip

Hyuna Yang, Yueming Ding, Gary A Churchill & Fernando Pardo-Manuel de Villena.
7th Annual Meeting of the Complex Trait Consortium in Montreal Canada, May-June 2008. Poster>

Epistatic Selection and Infertility in the Collaborative Cross

Fernando Pardo-Manuel de Villena.
Developmental Biology Symposium; George Watts Hill Alumni Center NC, March 28, 2008. Talk

Embracing Complexity: Mouse Models of Human Disease

Fernando Pardo-Manuel de Villena
Respiratory Virus Pathogenesis, Aging, and Models of ARDS Meeting, Chapel Hill NC, January 8, 2008. Talk

2007

Efficient Data Mining Methods Enabling Genome-wide Computing

Wei Wang and Fernando Pardo-Manuel de Villena.
Microsoft eScience Workshop at RENCI. October 2007. Talk

The Center for Genome Dynamics Research Overview (PDF 0.2 MB)

Randy Von Smith, Hyuna Yang, Petko M. Petkov, Timothy A. Bell,, Fernando Pardo-Manuel de Villena, Y. Zhang, R. Kirova, M.
A. Langston, E. J. Chesler, Renhua Li, Keith Shockley, David Witmer, Beverly Paigen, Gudrun A. Brockmann, Christina
Neuschl, Gary A. Churchill.
21st International Mammalian Genome Conference, Kyoto, Japan. October 2007. Poster

The Dependence of Computational Assignment of Putative SNPs on Choice of Alignment Tool (PDF 0.2 MB)

Deepti Anand, Lucie Hutchins, Joel H. Graber
7th IEEE Conference on Bioinformatics and BioEngineering, Boston, October 2007. Poster

On the subspecific origin of the laboratory mouse

Timothy A Bell, Hyuna Yang, Gary Churchill, Fenando Pardo-Manuel de Villena.
5th Annual Retreat Department of Genetics, Ashville NC, September 2007. Poster

Structural model analysis for adiposity in mice (PDF 0.1 MB)

Gudrun A Brockmann, Renhua Li, Christina Neuschl, Gary A Churchill
Meeting of the National Centers of Integrative and Systems Biology, Boston, June 2007. Poster

Modeling of systems genetics reveals genetic buffering mechanisms involved in HDL homeostatsis (PDF 0.2 MB)

Renhua Li, Gary A Churchill
Meeting of the National Centers of Integrative and Systems Biology, Boston, June 2007. Poster

The Center for Genome Dynamics at The Jackson Laboratory (PDF 0.04 MB)

Gary A Churchill
Meeting of the National Centers of Integrative and Systems Biology, Boston, June 2007. Poster

Trans-acting Factors Influence Several Mouse Meiotic Recombination Hotspots on Chromosome I (PDF 0.06 MB)

Emil Parvanov, Petko Petkov, Siemon Ng, Kenneth Paigen.
Meeting of the National Centers of Integrative and Systems Biology, Boston, June 2007. Poster

Linear Model Genome Scans for Expression QTL Analysis (PDF 0.2 MB)

Shirng-Wern Tsaih, Hyuna Yang, Renhua Li, Ioannis M. Stylianou, Keith DiPetrillo, Beverly Paigen, Gary A Churchill.
Meeting of the National Centers of Integrative and Systems Biology, Boston, June 2007. Poster

Comparison of Genetic Structure of Mouse Populations by Combinatorial Analysis of High-Order Long-Range Linkage Disequilibrium Networks Using High Density Genotypes (PDF 0.2 MB)

Yun Zhang, Roumyana Kirova, Gary A Churchill, Michael A Langston, Elissa J Chesler.
Meeting of the National Centers of Integrative and Systems Biology, Boston, June 2007. Poster

A Flexible Phylogenetic Tree Viewer (PDF 0.06 MB)

Aubrey A Smith , Joel H Graber, Gary A Churchill
Meeting of the National Centers of Integrative and Systems Biology, Boston, June 2007. Poster

PPARgamma2 Regulates Adipocyte Differentiation of Bone Marrow Mesenchymal Stem Cells (PDF 0.2 MB)

Keith R Shockley, Beata Lecka-Czernik, Clifford J Rosen, Gary A Churchill
Meeting of the National Centers of Integrative and Systems Biology, Boston, June 2007. Poster

A Hidden Markov Model for Inferring Haplotype Structure from Mouse SNP Data (PDF 0.3 MB)

Jin P Szatkiewicz, Glen L Beane, Gary A Churchill
Meeting of the National Centers of Integrative and Systems Biology, Boston, June 2007. Poster

Distribution and control of recombination activities in mouse (PDF 0.1 MB)

Siemon Ng, Petko M. Petkov, Rosie Madeira, Emil Parvanov, Kenneth Paigen
Meeting of the National Centers of Integrative and Systems Biology, Boston, June 2007. Poster

On the subspecific origin of the laboratory mouse (PDF 0.3 MB)

Hyuna Yang, Timothy A Bell, Gary Churchill, Fenando Pardo-Manuel de Villena.
Meeting of the National Centers of Integrative and Systems Biology, Boston, June 2007. Poster

Independent Studies in Computational Biology (PDF 0.07 MB)

Randy Von Smith, Deborah McGann, Keith Shockley, Shirngwern Tsaih, James Nadeau, Gary Churchill.
Meeting of the National Centers of Integrative and Systems Biology, Boston, June 2007. Poster

Recombination Landscape of Mouse Chromosomes

Petko PM.
10th International Meeting Spring in Lyon, May 14-16, 2007, Lyon, France. Talk

A Hidden Markov Model for Inferring Haplotype Structure from Mouse SNP Data (PDF 0.3 MB)

Jin P Szatkiewicz, Glen L Beane, Gary A Churchill
The International Biometric Society Eastern North American Region (ENAR) Spring Meeting, Atlanta, March 2007. Poster

On the Origin of the Laboratory Mouse: Lessons from the NIEHS Resequencing Project

Fernando Pardo-Manuel de Villena
Frontiers in Environmental Sciences, NIEHS, Research Triangle Park NC, March 30, 2007. Talk

2006

The origins of sex specificity of recombination

Petkov, PM, KW Broman, J Szatkiewicz, K Paigen
20th International Mammalian Genome Conference, Charleston SC, November 2006.

Genome wide phylogenetIc analysis and patterns of dIversity in sequenced mouse strains

Hyuna Yang, Timothy A Bell, Gary Churchill, Fernando Pardo-Manuel de Villena.
20th International Mammalian Genome Conference, Charleston SC, November 2006. Talk

False Negative Rate and SNP Discovery Bias in the NIEHS/Perlegen Mouse Diversity Project

Timothy A. Bell, Hyuna Yang, Gary Churchill, Fernando Pardo-Manuel de Villena.
20th International Mammalian Genome Conference, Charleston SC, November 2006. Poster