Project G: Using Multiple Phenotypes to Model Genetic Epistasis

Gregory W. Carter (Jackson)

 

Systems Genetics seeks to infer polygenic regulatory models of complex traits by identifying key genes and mapping networks that give rise to epistasis and plelotropy. The simultaneous modeling of multiple related phenotypes enables greater resolution of the interacting genetic network by providing a large set of constraints on possible solutions. This project is developing methods to exploit multidimensional phenotype data in genetic modeling of disease.

Center related publications

Inferring Gene Function and Network Organization in Drosophila Signaling by Combined Analysis of Pleiotropy and Epistasis
Carter GW.
G3 (Bethesda). 2013 Mar 18. pii: g3.113.005710v1. doi: 10.1534/g3.113.005710. PMCID: PMC3656728 [ Full Text ]

Predicting the effects of copy-number variation in double and triple mutant combinations
Carter GW, Hays M, Li S, Galitski T.
Pac Symp Biocomput. 2012:19-30. PMCID: PMC3334851 [ Full Text ]

Use of pleiotropy to model genetic interactions in a population
Carter GW, Hays M, Sherman A, Galitski T.
PLoS Genet. 2012;8(10):e1003010. doi: 10.1371/journal.pgen.1003010. PMCID: PMC3469415 [ Full Text ]

 

Project Leader

 

Project G