A new multi-PI R01 titled “Genetic Factors that Influence Arsenic Toxicity,” has been awarded to Principal Investigators Gary A. Churchill, Ron Korstanje, and Laura G. Reinholdt for November 1, 2018 through October 31, 2023.
Regulatory toxicology seeks to create safety thresholds for chemical exposure in humans based on experimental studies in animals, but results of such studies may not accurately predict human sensitivity because they fail to accommodate the genetic diversity that exists across human populations. We will use population-based, genetically diverse mice to study the complex interplay between genetic variation and environmental factors that determine cellular and organismal responses to arsenic exposure. Through a novel statistical analysis of our data, we will account for individual genetic variation and provide a data-driven model that can be translated to risk assessment for human chemical exposure.
Wall Street Journal - This Old Mouse: 'Golden Girls' Unlock the Mysteries of Aging
Ancient mice are important to research on aging people and command a higher price; Maine cousins live well past 125 human years. [Read More]
New Nature publication - Defining the consequences of genetic variation on a proteome-wide scale.
Combining two emerging large-scale technologies for the first time — multiplexed mass spectrometry and a mouse population with a high level of natural genetic diversity —researchers at Harvard Medical School (HMS) and The Jackson Laboratory (JAX) crack an outstanding question in biology and medicine: how genetic variants affect protein levels. [Read More]
Gary Churchill is a recipient of one of two new endowed chairs in genomics and computational biology established by a gift from David and Barbara Roux. The gift initiates the Roux Family Center for Genomics and Computational Biology at JAX campuses in Connecticut and Maine. Dr. Churchill has been appointed the Karl Gunnar Johansson Chair of Computational Biology, while Dr. Yijun Ruan has been named the Florine Deschenes Roux Chair of Genomics.
Bob Gotwals of the North Carolina School of Science and Matehmatics has received the National Association of Biology Teachers Genetics Education Award for his work with the Independent Studies in Computational Biology course, a research course offered to talented high school students from Maine, North Carolina and Georgia. The NABT Genetics Education Award is sponsored by the American Society for Human Genetics and the Genetics Society of America. [Read More]
Diversity Outbred mice emulate the breadth of human responses to the carcinogen benzene, according to a recent publication in Environmental Health Perspectives. Most toxicity testing is performed in animals with limited genetic diversity and risk assessors use standard multiplying factors when extrapolating from animals to humans.